Impaired Lef1 activation accelerates iPSC-derived keratinocytes differentiation in Progeria
Xiaojing Mao, Zheng‐Mei Xiong, Huijing Xue, Markus A. Brown, Yantenew G. Gete, Reynold Yu, Linlin Sun, Kan Cao
This study shows that impaired Lef1 activation in HGPS iPSCs accelerates keratinocyte differentiation, and base editing partially rescues this phenotype.
International Journal of Molecular Sciences · May 14, 2022Peer-reviewedDevelopmental Biology