Kan Cao

This paper introduces a microfluidic platform to study neurodegeneration in human neural circuits, identifying early electrophysiological biomarkers of disease progression.

This study compares network-level calcium dynamics in two in vitro Alzheimer's disease models, finding differences in hyperactivity and cell cooperation between familial AD and an accelerated model.

This study shows that impaired Lef1 activation in HGPS iPSCs accelerates keratinocyte differentiation, and base editing partially rescues this phenotype.