Persistent Na+ current couples seizure with spreading depolarization in Scn8a gain of function mice
Isamu Aiba, Yao Yu Ning, Jeffrey L. Noebels
This study shows that gain-of-function Scn8a mutations increase seizure and spreading depolarization in mice, and that persistent Na+ current contributes to this phenotype.
Brain · Apr 2, 2025Peer-reviewedNeuroscience