Isamu Aiba

This study shows that deleting EGR3 in Kcna1-null mice rescues seizures, behavior, and brain pathology, linking early seizures to long-term transcriptional changes.

This study shows that gain-of-function Scn8a mutations increase seizure and spreading depolarization in mice, and that persistent Na+ current contributes to this phenotype.

This study shows that hyperthermic seizures in Scn1a deficient mice trigger increased spreading depolarizations, which may contribute to epileptic encephalopathy.

This study shows that Emx1-Cre is expressed in peripheral autonomic ganglia involved in cardiorespiratory regulation, which may affect interpretations of transgenic mouse phenotypes.

This study identifies Kcnq2/Kv7.2 as a gene modulating spreading depolarization threshold and bilateral symmetry, with implications for epilepsy and migraine.

This study shows adrenergic agonists enhance intrinsic excitability of cardiac preganglionic neurons in the nucleus ambiguus via persistent sodium current.