CD24-dependent innate immune checkpoint targeting chimera disrupts TGF-β-driven immunosuppression to enhance anti-tumor therapy
Ziyue Cui, Zhaoyi Lu, Mingzhu Pan, Yefan Hu, Mengchen Gao, Anzhe Ma, Yaqi Hong, Yuguo Zhang, Xi Chen, Bo Wang, Juan Zhang
This paper develops a bifunctional antibody-fusion protein that targets CD24 and TGF-β1 to disrupt immunosuppression and enhance anti-tumor therapy.
bioRxiv · Sep 30, 2026 · PreprintImmunology