GABAA receptor mediated facilitation of proprioceptive afferent transmission to motoneurons is facilitated by TRPM8 channels on C-fibres that are gated by serotonin.
Sophie Black, Yaqing Li, Krishnapriya Hari, Shihao Lin, Nicole De Silvia, Temitayo O. Ayantayo, Marilee J. Stephens, Keith K. Fenrich, Ana M. Lucas‐Osma, Claire Francesca Meehan, Monica A. Gorassini, David J. Bennett
The paper shows serotonin inhibits nociceptive C-fibres and GABAergic input to proprioceptive Ia afferents, reducing motoneuron activity through TRPM8 and 5-HT1D receptor mechanisms.
bioRxiv · Feb 14, 2026 · PreprintNeuroscience