CTCF mediates the Activity-by-contact derived cis-regulatory hubs
Chang Jie Mick Lee, Loïc Mangnier, Cory C. Padilla, Dominic Paul Lee, Wilson Lek Wen Tan, Wen Hao Zheng, Louis Hanqiang Gan, Ching Kit Chen, Yee Phong Lim, Rina Miao Qin Wang, Peter Yiqing Li, Yonglin Zhu, Steve Bilodeau, Alexandre Bureau, Roger Foo, Chukwuemeka George Anene-Nzelu
The paper shows that CTCF loss in mouse heart cells reorganizes enhancer activity-by-contact scores, reduces CRH numbers, increases CRH size, and increases CRH crossing TAD boundaries.
International Journal of Molecular Sciences · Oct 9, 2025Peer-reviewedMolecular Biology