Roger Foo

Enzymatic extracellular matrix remodeling in ex vivo slices of aged myocardium

This study shows enzymatic remodeling of aged cardiac ECM reduces stiffness but preserves contractility and some age-related transcriptional features in ex vivo myocardial slices.

High throughput single-cell RNA sequencing of intact adult cardiomyocytes and non-myocytes using a split-pool approach

This paper develops a high-quality, scalable workflow for whole-cell single-cell RNA sequencing of adult cardiomyocytes and non-myocytes using in-cell ligation and split-pool barcoding, improving data quality and throughput.

Genetic liability to metabolic dysfunction modelled in early adulthood predicts cardiometabolic risk across the life course in Asian populations

This paper develops a polygenic score for metabolic syndrome in early adulthood and shows it predicts cardiometabolic risk across the life course in Asian populations.

Targeting Modulated Vascular Smooth Muscle Cells in Atherosclerosis via FAP-Directed Immunotherapy

Single-cell and spatial maps of human coronary arteries identify FAP as a marker of SMC-derived modulated cells; an anti-FAP BiTE reduced plaque burden in mouse models.

CTCF mediates the Activity-by-contact derived cis-regulatory hubs

The paper shows that CTCF loss in mouse heart cells reorganizes enhancer activity-by-contact scores, reduces CRH numbers, increases CRH size, and increases CRH crossing TAD boundaries.

Chromatin landscape and enhancer-gene interactiondifferences between three cardiac cell types

The paper identifies cell-type-specific enhancer-gene interactions in cardiac cells and maps disease-associated SNPs to enhancers in endothelial cells.

LIPTER, a cardiomyocyte-enriched long noncoding RNA, controls cardiac cytoskeletal maturation and is regulated by a cardiomyocyte-specific enhancer.

The paper identifies LIPTER, a cardiomyocyte-specific long noncoding RNA, and shows it regulates cytoskeletal maturation and is controlled by a cardiomyocyte-specific enhancer.

Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery

This study identifies RUNX1 as a key regulator of cardiac recovery by reprogramming macrophages, showing that its inhibition promotes heart function recovery in a chronic heart failure model.

Mapping DNA Methylation to Cardiac Pathologies Induced by Beta-Adrenergic Stimulation in a Large Panel of Mice

This study identifies DNA methylation loci associated with heart failure in mice, showing their functional relevance and therapeutic potential through in vitro and in vivo experiments.

Macrophage-like vascular smooth muscle cells dominate early atherosclerosis and are inhibited by targeting iron regulation

The paper identifies macrophage-like vascular smooth muscle cells as dominant in early atherosclerosis and shows that targeting iron regulation inhibits their transition.

Coronary Artery Disease Risk Variant rs6903956 Links to Endothelial Dysfunction via PHACTR1 Regulation

This study identifies rs6903956 as a CAD risk variant that regulates endothelial dysfunction through PHACTR1 and EDN1 expression via HOXA4 and MEIS1 binding.

Single cell variant to enhancer to gene map for coronary artery disease

This paper links CAD GWAS variants to causal genes in SMCs using single-cell chromatin accessibility and Hi-C data, creating a scV2E2G map for disease mechanism discovery.

Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac development and early indicators of cardiac risk

This study identifies 194 epigenome-wide significant CpGs associated with dilated cardiomyopathy (DCM) and links them to cardiac gene expression and cardiovascular risk factors.

Rockfish: A Transformer-based Model for Accurate 5-Methylcytosine Prediction from Nanopore Sequencing

Rockfish improves 5-methylcytosine detection from Nanopore sequencing with higher accuracy and efficiency compared to existing methods.

Metabolome-wide association of carotid intima media thickness identifies FDX1 as a determinant of cholesterol metabolism and cardiovascular risk in Asian populations.

Trans-interaction of risk loci 6p24.1 and 10q11.21 is associated with endothelial damage in coronary artery disease

Integrative Epigenomic and Transcriptomic Analysis Reveals Robust Metabolic Switching in the Brain During Intermittent Fasting

This study shows intermittent fasting modulates H3K9me3 epigenetic marks and transcriptomic changes in mouse cerebellum, with lasting effects after refeeding.

Large-scale whole-genome sequencing of three diverse Asian populations in Singapore

This study presents whole-genome sequencing data from 4,810 Singaporeans across three ethnic groups, revealing genetic structure, admixture, and improved imputation for Asian and Oceanian populations.

Gene neighbourhood integrity disrupted by CTCF loss in vivo

This study shows that loss of CTCF in mouse cardiomyocytes disrupts gene neighbourhoods, leading to ectopic enhancer-promoter interactions and heart failure.

Disease and phenotype relevant genetic variants identified from histone acetylomes in human hearts

The paper identifies genetic variants associated with heart failure by analyzing histone acetylation QTLs in human heart tissue.