GPC6 Lipid Shielding Sustains WNT5A Gradients to Prevent a RASopathy-like Developmental State
Yeonjoo Kim, Yuguang Zhao, Aurora Xinshu Xu, Asif Nakhuda, Ana-Miruna Androniciuc, Gennadiy Tenin, Bernard D. Keavney, E. Yvonne Jones, Ian John McGough
The paper shows that GPC6 shields WNT5A lipid to maintain gradients, and its disruption causes a RASopathy-like developmental state by promoting premature signaling.
bioRxiv · Sep 22, 2026 · PreprintDevelopmental Biology