Author

Aurora Xinshu Xu

Babraham Institute

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Developmental Biology· 1

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Approach:experimental assay· 1 Organism:mouse· 1

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Ana-Miruna Androniciuc· 1 shared Asif NakhudaiD· 1 shared Bernard D. KeavneyiD· 1 shared E. Yvonne JonesiD· 1 shared Gennadiy TeniniD· 1 shared Ian John McGoughiD· 1 shared Yeonjoo Kim· 1 shared Yuguang ZhaoiD· 1 shared

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Ana-Miruna Androniciuc

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Recent·Most cited

Developmental BiologybioRxivPreprintSep 22, 2026

GPC6 Lipid Shielding Sustains WNT5A Gradients to Prevent a RASopathy-like Developmental State

Yeonjoo Kim, Yuguang Zhao, Aurora Xinshu Xu…·Ian John McGough

The paper shows that GPC6 shields WNT5A lipid to maintain gradients, and its disruption causes a RASopathy-like developmental state by promoting premature signaling.

DOI 10.64898/2026.09.20.752969

mouseexperimental assay

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