AAV-delivered CRISPR-Cas9 elicits persistent retinal immune responses compared with transient responses to RNP
Juliette Pulman, Duohao Ren, Laura Visticot, Hugo Malki, Yeqian Yao, Anne De Cian, Divya Ail, Jean‐Paul Concordet, Deniz Dalkara, Sylvain Fisson
This study compares immune responses to AAV-delivered CRISPR-Cas9 and RNP-delivered CRISPR-Cas9 in the retina, finding persistent inflammation with AAV and transient inflammation with RNP.
bioRxiv · Dec 14, 2025 · PreprintBioengineering