AAV-delivered CRISPR-Cas9 elicits persistent retinal immune responses compared with transient responses to RNP
Juliette Pulman, Duohao Ren, Laura Visticot…·Sylvain Fisson
This study compares immune responses to AAV-delivered CRISPR-Cas9 and RNP-delivered CRISPR-Cas9 in the retina, finding persistent inflammation with AAV and transient inflammation with RNP.