Xist RNA binds select autosomal genes and depends on Repeat B to regulate their expression
Shengze Yao, Yesu Jeon, Barry Kesner, Jeannie T. Lee
This study shows Xist RNA binds ~100 autosomal genes beyond the inactive X chromosome, with Repeat B essential for its function, and identifies a small molecule inhibitor that disrupts this activity.
eLife · Jun 9, 2025Peer-reviewedGenomics