A transient protein folding response targets aggregation in the early phase of TDP-43-mediated disease
Rebecca San Gil, Dana Pascovici, Juliana Venturato, Heledd Brown-Wright, Prachi M. Mehta, Lidia Madrid San Martin, Jemma X. Wu, Yi Kit Chui, Adekunle T. Bademosi, Shilpa Swaminathan, Wei Luan, Britt A. Berning, Amanda L. Wright, Sean S. Keating, Albert Lee, , Adam K. Walker
This study identifies a transient protein folding response in early TDP-43 disease that reduces aggregation, with DNAJB5 as a protective factor, and shows proteomic similarities between mouse and human TDP-43 proteinopathies.
bioRxiv · Jun 21, 2023 · PreprintNeuroscience