Nucleolar Pol II interactome reveals TBPL1, PAF1, and Pol I at intergenic rDNA drive rRNA biogenesis
Negin Khosraviani, V. Talya Yerlici, Jonathan R. St‐Germain, Yi Yang Hou, Shi Bo Cao, Carla Ghali, Michael Bokros, Rehna Krishnan, Razqallah Hakem, Stephen Lee, Brian Raught, Karim Mekhail
The paper identifies TBPL1 and PAF1 as regulators of Pol II at the intergenic spacer (IGS) of rDNA, showing their role in controlling Pol I activity and maintaining nucleolar structure and rRNA biogenesis.
Nature Communications · Nov 6, 2024Peer-reviewedMolecular Biology