Author

V. Talya Yerlici

Columbia UniversityORCID 0000-0001-5408-0518Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Brian RaughtiD· 1 shared Carla GhaliiD· 1 shared Dan LouiD· 1 shared Daniel Kirrmaier· 1 shared Derek M. Clay· 1 shared Jananan Sylvestre Pathmanathan· 1 shared Jaspreet S. Khurana· 1 shared Jonathan R. St‐GermainiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMolecular Biology

Brian RaughtORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintDec 16, 2025

Improved cloning-free one-step CRISPR-Cas12a-assisted tagging of mammalian genes using PCR generated reagents (PCR tagging)

Dan Lou, Daniel Kirrmaier, Melanie Krause…·Michael Knop

The paper improves CRISPR-Cas12a-assisted gene tagging in mammalian cells by enhancing HDR efficiency and reducing off-target integrations through modified cassettes and repair pathway modulation.

1 citation

humanCRISPR screen

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Molecular BiologyNature CommunicationsPeer-reviewedNov 6, 2024

Nucleolar Pol II interactome reveals TBPL1, PAF1, and Pol I at intergenic rDNA drive rRNA biogenesis

Negin Khosraviani, V. Talya Yerlici, Jonathan R. St‐Germain…·Karim Mekhail

The paper identifies TBPL1 and PAF1 as regulators of Pol II at the intergenic spacer (IGS) of rDNA, showing their role in controlling Pol I activity and maintaining nucleolar structure and rRNA biogenesis.

11 citations

humanDNA methylation

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GenomicsG3 Genes Genomes GeneticsPeer-reviewedMar 27, 2021

Transcribed germline-limited coding sequences in Oxytricha trifallax

Richard V. Miller, Rafik Neme, Derek M. Clay…·Laura F. Landweber

The paper identifies and characterizes transcribed germline-limited ORFs in Oxytricha trifallax, showing they are developmentally regulated and eliminated during genome rearrangement.

7 citations

experimental assay

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