Author

Rehna Krishnan

University Health NetworkORCID 0000-0002-0583-9687Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Karim MekhailiD· 3 shared Anisha K. HundaliD· 2 shared Anne HakemiD· 2 shared Defne UrmaniD· 2 shared Jun HaoiD· 2 shared Philipp G. MaassiD· 2 shared Razqallah HakemiD· 2 shared Adam T RybczynskiiD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersMolecular Biology

Karim MekhailORCID

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3 papers

Recent·Most cited

A Distributed Architectural Code Governs DNA Repair

Anisha K. Hundal, Defne Urman, Araad Algouneh, Rehna Krishnan, Chris A. Jordan, Sergei Rudnizky, Adam T Rybczynski, Tamari Chkuaseli, Anne Hakem, Jun Hao, Philipp G. Maass, Taekjip Ha, Razq Hakem, Karim Mekhail

The paper identifies a distributed architectural code involving cytoskeletal, membrane, and lipid regulators that governs nuclear reshaping during DNA repair.

bioRxiv · Oct 19, 2026 · PreprintMolecular Biology

Nucleolar Pol II interactome reveals TBPL1, PAF1, and Pol I at intergenic rDNA drive rRNA biogenesis

Negin Khosraviani, V. Talya Yerlici, Jonathan R. St‐Germain, Yi Yang Hou, Shi Bo Cao, Carla Ghali, Michael Bokros, Rehna Krishnan, Razqallah Hakem, Stephen Lee, Brian Raught, Karim Mekhail

The paper identifies TBPL1 and PAF1 as regulators of Pol II at the intergenic spacer (IGS) of rDNA, showing their role in controlling Pol I activity and maintaining nucleolar structure and rRNA biogenesis.

Nature Communications · Nov 6, 2024Peer-reviewedMolecular Biology

DNA double-strand break-capturing nuclear envelope tubules drive DNA repair

Mitra Shokrollahi, Mia Stanić, Anisha K. Hundal, Janet N.Y. Chan, Defne Urman, Chris A. Jordan, Anne Hakem, Roderic Espín, Jun Hao, Rehna Krishnan, Philipp G. Maass, Brendan Craig Dickson, Manoor Prakash Hande, Miguel Ángel Pujana, Razqallah Hakem, Karim Mekhail

The paper shows that DNA double-strand breaks are repaired by nuclear envelope tubules formed through cytoplasmic microtubule interactions, enhancing repair accuracy and cancer therapy efficacy.

Nature Structural & Molecular Biology · Apr 17, 2024Peer-reviewedMolecular Biology