De Novo Negatively Charged Binders Targeting MMLVRT Nucleic Acid Binding Sites Overcome Stability-Activity Trade-offs
Yibo Zhu, Hongwei Liu, Fang Qu, Yingzhi Wang, JuanJuan Yao, Shumin You, Lin Hua, Chunlei Ge, Hong Yao, Tao Li
This paper designs negatively charged binders that enhance the stability of MMLV RT without affecting its activity, overcoming stability-activity trade-offs.
bioRxiv · Mar 15, 2025 · PreprintBioengineering