Ionizable Lipids Promote Curvature Remodeling and Altered Fluctuation Dynamics in Endosomal Membranes
Teshani Kumarage, Yiding Li, Bengu Sueda Sengul, Mayesha B. Mustafa, Jinchao Lou, Michael D. Best, Charles M. Schroeder, Cecília Leal
This study investigates how ionizable lipids alter endosomal membrane properties to enhance endosomal escape, showing they reduce membrane rigidity and curvature.
bioRxiv · Aug 20, 2026 · PreprintBiophysics