TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry
Yifan Xie, Jie Cao, Shuyi Gan, Ling-Dong Xu, Dongjie Zhang, Suhong Qian, Feng Xu, Qiang Ding, John W. Schoggins, Wenchun Fan
This paper identifies TRIM32 as an intrinsic restriction factor against alphavirus infection, showing it inhibits viral genome translation through monoubiquitination and that disease mutants lose this antiviral activity.
PLoS Pathogens · Nov 11, 2024Peer-reviewedMicrobiology