Author

John W. Schoggins

The University of Texas Southwestern Medical CenterORCID 0000-0002-7944-6800Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

John W. Schoggins1 paper · The University of Texas Southwestern Medical Center

Biology Disciplines

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Microbiology· 2 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Approach:deep learning· 1

Frequent Co-Authors

Jennifer L. Eitson· 2 shared Abir MajumdariD· 1 shared Adam OsinskiiD· 1 shared Anthony M De MariaiD· 1 shared Bruce A. PosneriD· 1 shared Dongjie ZhangiD· 1 shared Emi NakaharaiD· 1 shared Feng XuiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

Jennifer L. Eitson

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4 papers

Recent·Most cited

IFIT1 is rapidly evolving and exhibits disparate antiviral activities across 11 mammalian orders

Matthew B. McDougal, Ian N. Boys, Anthony M De Maria, Emi Nakahara, John W. Schoggins

The paper shows IFIT1 genes evolve rapidly across mammals and exhibit varying antiviral activities against viruses like VEEV.

eLife · Oct 22, 2025Peer-reviewedMicrobiology

Covalent inhibition of the SARS-CoV-2 NiRAN domain via an active-site cysteine

Genaro Hernandez, Adam Osinski, Abir Majumdar, Jennifer L. Eitson, Monika I. Antczak, Krzysztof Pawłowski, Hanspeter Niederstrasser, Kelly A. Servage, Bruce A. Posner, John W. Schoggins, Joseph M. Ready, Vincent S. Tagliabracci

The paper identifies NCI-2, a covalent inhibitor of the SARS-CoV-2 NiRAN domain, and presents a structural blueprint for drug design.

Journal of Biological Chemistry · Mar 4, 2025Peer-reviewedBiochemistry

TRIM32 inhibits Venezuelan Equine Encephalitis Virus Infection by targeting a late step in viral entry

Yifan Xie, Jie Cao, Shuyi Gan, Ling-Dong Xu, Dongjie Zhang, Suhong Qian, Feng Xu, Qiang Ding, John W. Schoggins, Wenchun Fan

This paper identifies TRIM32 as an intrinsic restriction factor against alphavirus infection, showing it inhibits viral genome translation through monoubiquitination and that disease mutants lose this antiviral activity.

PLoS Pathogens · Nov 11, 2024Peer-reviewedMicrobiology

IRF7 from the black flying fox induces a STAT1-independent ISG response in unstimulated cell lines that protects against diverse RNA viruses

Pamela C. De La Cruz-Rivera, Jennifer L. Eitson, John W. Schoggins

This study identifies IRF7 from the black flying fox as a potent antiviral molecule that induces an ISG response independent of STAT1, providing broad protection against multiple RNA viruses.

bioRxiv · May 2, 2024 · PreprintImmunology