Chronic intermittent nicotine delivery with lung alveolar region-targeted aerosol technology produces circadian blood pharmacokinetics in rats resembling human smokers
Xuesi M. Shao, Siyu Liu, Eon S. Lee, David Fung, Hua Pei, Jing Liang, Ross Mudgway, Jingxi Zhang, Jack L. Feldman, Yifang Zhu, Stan Louie, Xinmin S Xie
This paper develops a nicotine aerosol delivery system in rats that mimics human smoking pharmacokinetics, showing similar circadian nicotine and cotinine levels.
bioRxiv · Sep 27, 2017 · PreprintPharmacology & Toxicology