Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis
Drew W. Grant, Shengjiang Tan, Dylan E. Ramage, Mamie Z. Li, Ying Di, Iva A. Tchasovnikarova, Michael P. Weekes, Stephen Joseph Elledge, Alan John Warren, Richard T. Timms
The paper identifies C-terminal degron substrates of the CTLH E3 ligase complex and links their regulation to ribosome biogenesis through the chaperone activity of AAMP.
bioRxiv · Jan 14, 2026 · PreprintMolecular Biology