Michael P. Weekes

This study identifies HSV-1 protein pUL56 as responsible for removing voltage-gated ion channels from neuronal plasma membranes, disrupting calcium signaling and neuronal activity.

This study assesses cross-neutralisation of sarbecoviruses by COVID-19 vaccines in older adults, finding reduced neutralisation of Omicron variants and some animal sarbecoviruses but enhanced neutralisation of specific bat and pangolin coronaviruses.

The paper identifies LRRC58 as a substrate adaptor in a Cul2 E3 ligase complex that regulates CDO1 degradation in response to cysteine availability, preventing ferroptosis and neurodevelopmental defects.

The paper identifies novel proteins that relocalize in adipocytes in response to insulin, highlighting their role in insulin signaling.

The paper investigates whether Plasmodium falciparum parasites preferentially invade Duffy-positive red blood cells and explores the evolutionary implications for Duffy negativity prevalence.

The paper identifies C-terminal degron substrates of the CTLH E3 ligase complex and links their regulation to ribosome biogenesis through the chaperone activity of AAMP.

This paper identifies gpUL141 as a HCMV virion component that modulates envelope glycoprotein trafficking to evade humoral immunity.

The paper identifies a novel CRTC-dependent viral sensing pathway that promotes interleukin-11 production during viral infection.

The paper uses proteomic analysis to study HCMV-infected dendritic cells, revealing how the virus manipulates adaptive immunity and restricts replication.

The paper shows that Dantu blood group variant increases red blood cell tension, reducing Plasmodium falciparum invasion and protecting against severe malaria.

The paper describes the development of a validated SARS-CoV-2 diagnostic workflow in an academic laboratory to support local screening during the pandemic.