Author
University of CambridgeORCID 0000-0002-0477-0956Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Roopali Pradhan, Anna F. Townley, Anna Victoria Protasio…·Julie Ahringer
The paper identifies activation of the innate immune stress pathway as a mechanism linking heterochromatin dysfunction to pathological phenotypes in C. elegans and human cells.
Dylan E. Ramage, Lianne H. E. Wieske, Charlotte Crowe…·Richard T. Timms
The paper identifies LRRC58 as a substrate adaptor in a Cul2 E3 ligase complex that regulates CDO1 degradation in response to cysteine availability, preventing ferroptosis and neurodevelopmental defects.
Drew W. Grant, Shengjiang Tan, Dylan E. Ramage…·Richard T. Timms
The paper identifies C-terminal degron substrates of the CTLH E3 ligase complex and links their regulation to ribosome biogenesis through the chaperone activity of AAMP.
Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms…·Yorgo Modis
The paper identifies TASOR as a pseudo-PARP essential for HUSH complex assembly and epigenetic repression of transposons.