Multimodal single cell-resolved spatial proteomics reveals pancreatic tumor heterogeneity
Yanfen Xu, Xi Wang, Yuan Li, Yiheng Mao, Yiran Su, Yize Mao, Yun Yang, Weina Gao, Changying Fu, Wendong Chen, Xueting Ye, Fuchao Liang, Panzhu Bai, Ying Sun, Shengping Li, , Ruijun Tian
The paper introduces SCPro, a multimodal spatial proteomics method, to profile pancreatic tumor heterogeneity by integrating imaging, flow cytometry, and protein aggregation capture, revealing spatial proteome variations and a novel regulatory T cell subtype.
Nature Communications · Nov 21, 2024Peer-reviewedSystems Biology