Author

Weina Gao

Southern University of Science and TechnologyORCID 0000-0002-1645-8513Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 2 Bioinformatics· 1 Cancer Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 4 Research Focus:cell type annotation· 2 Research Focus:deconvolution· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Ruijun TianiD· 5 shared Yanfen Xu· 3 shared Yiheng MaoiD· 3 shared An HeiD· 2 shared Ruilian XuiD· 2 shared Ben HuiD· 1 shared Binbin ZhengiD· 1 shared Changying FuiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersSystems Biology

Ruijun TianORCID

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Author profile →

5 papers

Recent·Most cited

AutoPELSA: an automated sample preparation system for proteome-wide identification of target proteins of diverse ligands

Lianji Xue, Xi Wang, Haiqian Yang, Jie Zhou, Hao Zhu, Jinhua Shen, Weina Gao, Ruijun Tian, Yan Wang, Mingliang Ye

AutoPELSA automates the PELSA workflow for proteome-wide ligand-protein interaction detection, enabling high-throughput analysis of both strong and low-affinity ligands.

Analytical Chemistry · Jun 29, 2026Peer-reviewedMolecular Biology

Spatial-DC: a robust deep learning-based method for deconvolution of spatial proteomics

Y Li, Qian Kong, Zihan Wu, Yanfen Xu, Yiheng Mao, Yunjie Gu, X Wang, Weina Gao, Ruijun Tian, Jianhua Yao

Spatial-DC improves spatial proteomics deconvolution by using deep learning to infer cell-type composition and reconstruct proteomic profiles from low-resolution data.

Cell Systems · May 27, 2026Peer-reviewedBioinformatics

Evaluation of the nano Liquid Chromatography coupled with Zeno TOF 7600 Mass Spectrometer for Cell Type-Resolved Spatial Proteomics

Keren Zhang, Xi Wang, Wan He, Jiani Wang, An He, Binbin Zheng, Yangqiu Li, Ruilian Xu, Weina Gao, Henry Lam, Ruijun Tian

The paper evaluates a nanoLC-Zeno TOF platform for spatial proteomics, identifying protein groups and differential expression in gastric cancer tissue.

bioRxiv · Jun 23, 2025 · PreprintCancer Biology

Multimodal single cell-resolved spatial proteomics reveals pancreatic tumor heterogeneity

Yanfen Xu, Xi Wang, Yuan Li, Yiheng Mao, Yiran Su, Yize Mao, Yun Yang, Weina Gao, Changying Fu, Wendong Chen, Xueting Ye, Fuchao Liang, Panzhu Bai, Ying Sun, Shengping Li, , Ruijun Tian

The paper introduces SCPro, a multimodal spatial proteomics method, to profile pancreatic tumor heterogeneity by integrating imaging, flow cytometry, and protein aggregation capture, revealing spatial proteome variations and a novel regulatory T cell subtype.

Nature Communications · Nov 21, 2024Peer-reviewedSystems Biology

Deep spatial proteomic exploration of severe COVID-19-related pulmonary injury in post-mortem specimens

Yiheng Mao, Ying Chen, Yuan Li, Longda Ma, Xi Wang, Qi Wang, An He, Xi Liu, Tianyi Dong, Weina Gao, Yanfen Xu, Liang Liu, Liang Ren, Qian Liu, Peng Zhou, , Zheng‐Li Shi

This study creates a spatial proteomic atlas of lung tissues from COVID-19 victims, identifying protein dysregulations and markers of pathological changes.

bioRxiv · Jul 14, 2023 · PreprintSystems Biology