Wendong Chen

This study uses phosphotyrosine proteomics to analyze CAR-T cells from patients and donors, finding heightened tyrosine phosphorylation and tonic signaling linked to therapeutic efficacy.

The paper introduces SCPro, a multimodal spatial proteomics method, to profile pancreatic tumor heterogeneity by integrating imaging, flow cytometry, and protein aggregation capture, revealing spatial proteome variations and a novel regulatory T cell subtype.

DeepRTAlign improves retention time alignment for large cohort LC-MS data, enhancing identification sensitivity without compromising quantitative accuracy and enabling predictive modeling for hepatocellular carcinoma recurrence.