Author

Yiwen Gong

University of Electronic Science and Technology of China

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 2 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Organism:C. elegans· 2 Approach:statistical model· 2 Approach:machine learning (classical)· 1 Assay:proteomics· 1

Frequent Co-Authors

Hongxia CaiiD· 3 shared Guojun LiiD· 2 shared Junyu Ning· 2 shared Ruofei Li· 2 shared Yan PaniD· 2 shared Yutong LiiD· 2 shared Anastasia Ngozi Ezemaduka· 1 shared Bo XianiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBioinformatics

Hongxia CaiORCID

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3 papers

Recent·Most cited

Discovery of Selective Nrf2 Activators from Natural Products: AComputational Screening Approach to Minimize Off-Target Effects on PXR and CYP2D6

Yue Wang, Yiwen Gong, Ruofei Li, Zhiru Li, Hongxia Cai, Li Fan, Yutong Li, Haomiao Ma

This paper identifies 10 ultraselective Nrf2 activators from natural products using computational screening to minimize off-target effects on PXR and CYP2D6.

bioRxiv · Apr 15, 2026 · PreprintBioinformatics

De Novo Design of Anti-Aging Peptides

Yan Pan, Fan Li, Nan Zhang, Jiexin Zheng, Zhong Jin, Hongxia Cai, Hongbao Ma, Wenjing Zhang, Jingyuan Zhu, Wentao Xu, Yiwen Gong, Ruofei Li, Rui Liang, Guojun Li, Haiming Jing, , Bo Xian

This paper introduces ElixirSeeker2, a computational framework for de novo design of anti-aging peptides, which identifies novel candidates effective in delaying cellular senescence and improving locomotor activity in aged C. elegans.

bioRxiv · Oct 4, 2025 · PreprintBioinformatics

ElixirSeeker: A Machine Learning Framework Utilizing Attention-Driven Fusion of Molecular Fingerprints for the Discovery of Anti-Aging Compounds

Yan Pan, Hongxia Cai, Fang Ye, Wentao Xu, Zhihang Huang, Jingyuan Zhu, Yiwen Gong, Yutong Li, Anastasia Ngozi Ezemaduka, Shan Gao, Shunqi Liu, Guojun Li, Hao Li, H. J. Yang, Junyu Ning, Bo Xian

ElixirSeeker uses attention-driven fusion of molecular fingerprints to identify anti-aging compounds, finding four that extend C. elegans lifespan.

bioRxiv · Sep 8, 2024 · PreprintSystems Biology