Counter-regulation of RNA stability by UPF1 and TDP43
Nicolás Gómez, Caroline Hsieh, Xingli Li, Megan M. Dykstra, Jacob Waksmacki, Christopher H. Altheim, Yoel Bechar, Joseph R. Klim, Benjamin L. Zaepfel, Jeffrey D. Rothstein, Elizabeth M.H. Tank, Sami J. Barmada
The paper develops NMDq, a next-generation sequencing method to quantify NMD status, and applies it to ALS and FTD, finding no significant PTC differences but showing UPF1 regulates RNA homeostasis through alternative polyadenylation.
bioRxiv · Jan 31, 2024 · PreprintNeuroscience