Author

Christopher H. Altheim

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Jacob Waksmacki· 2 shared Nicolás GómeziD· 2 shared Sami J. BarmadaiD· 2 shared Xingli LiiD· 2 shared Benjamin L. ZaepfeliD· 1 shared Caroline Hsieh· 1 shared Elizabeth M.H. TankiD· 1 shared Evrim YildirimiD· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersNeuroscience

Jacob Waksmacki

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2 papers

Recent·Most cited

Stress granule formation helps to mitigate neurodegeneration

M. Rebecca Glineburg, Evrim Yildirim, Nicolás Gómez, Genesis Rodriguez, Jaclyn Pak, Xingli Li, Christopher H. Altheim, Jacob Waksmacki, Gerald M. McInerney, Sami J. Barmada, Peter K. Todd

This study investigates the role of stress granule formation in neurodegeneration, finding that reducing stress granules exacerbates disease phenotypes in models of ataxia, ALS, and FTD.

Nucleic Acids Research · Jul 17, 2024Peer-reviewedNeuroscience

Counter-regulation of RNA stability by UPF1 and TDP43

Nicolás Gómez, Caroline Hsieh, Xingli Li, Megan M. Dykstra, Jacob Waksmacki, Christopher H. Altheim, Yoel Bechar, Joseph R. Klim, Benjamin L. Zaepfel, Jeffrey D. Rothstein, Elizabeth M.H. Tank, Sami J. Barmada

The paper develops NMDq, a next-generation sequencing method to quantify NMD status, and applies it to ALS and FTD, finding no significant PTC differences but showing UPF1 regulates RNA homeostasis through alternative polyadenylation.

bioRxiv · Jan 31, 2024 · PreprintNeuroscience