Author

Caroline Hsieh

University of Michigan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

Elizabeth M.H. TankiD· 2 shared Nicolás GómeziD· 2 shared Sami J. BarmadaiD· 2 shared Xingli LiiD· 2 shared Benjamin L. ZaepfeliD· 1 shared Christopher H. Altheim· 1 shared Jacob Waksmacki· 1 shared Jeffrey D. RothsteiniD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Elizabeth M.H. TankORCID

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3 papers

Recent·Most cited

Host brain environmental influences on transplanted medial ganglionic eminence progenitors

Rosalia Paternò, Thy Vu, Caroline Hsieh, Scott C. Baraban

This study evaluates how host brain age and region affect the survival, migration, and differentiation of transplanted MGE progenitors, finding that early postnatal transplantation yields better outcomes.

Scientific Reports · Feb 13, 2024Peer-reviewedNeuroscience

Counter-regulation of RNA stability by UPF1 and TDP43

Nicolás Gómez, Caroline Hsieh, Xingli Li, Megan M. Dykstra, Jacob Waksmacki, Christopher H. Altheim, Yoel Bechar, Joseph R. Klim, Benjamin L. Zaepfel, Jeffrey D. Rothstein, Elizabeth M.H. Tank, Sami J. Barmada

The paper develops NMDq, a next-generation sequencing method to quantify NMD status, and applies it to ALS and FTD, finding no significant PTC differences but showing UPF1 regulates RNA homeostasis through alternative polyadenylation.

bioRxiv · Jan 31, 2024 · PreprintNeuroscience

RNA methylation influences TDP43 binding and disease pathogenesis in models of amyotrophic lateral sclerosis and frontotemporal dementia

Michael McMillan, Nicolás Gómez, Caroline Hsieh, Michael E. Bekier, Xingli Li, Roberto Miguez, Elizabeth M.H. Tank, Sami J. Barmada

This study shows that RNA methylation influences TDP43 binding and contributes to neurodegeneration in ALS by modulating RNA stability and TDP43 function.

Molecular Cell · Jan 1, 2023Peer-reviewedNeuroscience