In vivo KRAS G12D/V Degradation Mediated by CANDDY Using a Modified Proteasome Inhibitor
Satoshi Imanishi, Lijuan Huang, Shoko Itakura, Masamichi Ishizaka, Yoichi Iwasaki, Tomohiro Yamaguchi, Etsuko Miyamoto‐Sato
This paper develops a chemical knockdown strategy called CANDDY to degrade KRAS G12D/V mutants in vivo, showing tumor suppression through proteasomal degradation independent of ubiquitination.
bioRxiv · Apr 23, 2021 · PreprintMolecular Biology