Molecular BiologybioRxivPreprint
In vivo KRAS G12D/V Degradation Mediated by CANDDY Using a Modified Proteasome Inhibitor
Satoshi Imanishi, Lijuan Huang, Shoko Itakura…·Etsuko Miyamoto‐Sato
This paper develops a chemical knockdown strategy called CANDDY to degrade KRAS G12D/V mutants in vivo, showing tumor suppression through proteasomal degradation independent of ubiquitination.
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