Predicting VHH-Fc Developability from Large-Scale IgG Data
Joshua Moller, Seth Ritter, Laura M. Rand, Alexander Smith, Yolaine Pierre, Tim Bloomingdale, Blake Harris, Sai Karthick, Lucía Daniela Grippo, Aanal Bhatt, Jay Patel, Xiang Ao, Rebecca Bhatt, Rich Cohen, David W. Borhani, , Ammar Arsiwala
The paper introduces a dataset of VHH-Fc antibodies and shows that IgG-trained models outperform VHH-Fc-specific models in predicting developability properties.
bioRxiv · Aug 21, 2026 · PreprintBiophysics