CD38 defines a therapeutically targetable pathogenic T cell population for precision immunotherapy in autoimmune diabetes
Shiva Pathak, Rizwan Ahmed, Nadine Nagy, Sooyeon Lee, Cameron S. Bader, Shobha Regmi, Bettina Panagiota Iliopoulou, Pin-I Chen, Biki Gupta, Alejandro Villar‐Prados, Yong Bin Kim, Noor A. Hussein, Emily Soohoo, Abigail Twoy, Avnesh Sinh Thakor, , Everett H. Meyer
The paper identifies CD38 as a marker for pathogenic T cells in T1D and shows that anti-CD38 mAb selectively depletes these cells to prevent diabetes without affecting Tregs.
bioRxiv · Jul 3, 2026 · PreprintImmunology