Shiva Pathak

This study identifies donor-derived CD8+CD122+ Tregs in mixed chimeric NOD mice that suppress autoreactive T cells and may offer a new therapeutic strategy for autoimmune diabetes.

The paper identifies CD38 as a marker for pathogenic T cells in T1D and shows that anti-CD38 mAb selectively depletes these cells to prevent diabetes without affecting Tregs.

This study identifies a conditioning regimen that promotes mixed hematopoietic chimerism and islet tolerance to cure diabetes in mice with minimal radiation.

This study demonstrates that non-myeloablative conditioning with anti-CD117 antibodies and HCT can induce durable mixed chimerism and cure autoimmune diabetes in NOD mice.