TDP-43 mutations-induced defects in miRNA biogenesis and cytotoxicity by differentially obstructing Dicer activity in Drosophila and in vitro
Xiang Long, Mengni Jiang, Yongzhen Miao, Huanhuan Du, Ting Zhang, Zhuoya Ma, Jiao Jiao Li, Chun‐Feng Liu, Hongrui Meng
This study shows TDP-43 mutations disrupt miRNA biogenesis by affecting Dicer activity, leading to cytotoxicity in Drosophila and in vitro models.
bioRxiv · Jul 10, 2024 · PreprintMolecular Biology