Molecular BiologybioRxivPreprint
TDP-43 mutations-induced defects in miRNA biogenesis and cytotoxicity by differentially obstructing Dicer activity in Drosophila and in vitro
Xiang Long, Mengni Jiang, Yongzhen Miao…·Hongrui Meng
This study shows TDP-43 mutations disrupt miRNA biogenesis by affecting Dicer activity, leading to cytotoxicity in Drosophila and in vitro models.
DOI 10.1101/2024.07.10.602849