Multiplexed Assays of Human Disease-relevant Mutations Reveal UTR Dinucleotide Composition as a Major Determinant of RNA Stability
Jia-Ying Su, Yun-Lin Wang, Yu-Tung Hsieh, Yu-Chi Chang, Cheng‐Han Yang, YoonSoon Kang, Yen‐Tsung Huang, Chien‐Ling Lin
The paper identifies UA dinucleotides as a major determinant of RNA stability through UTR variants, linking them to disease and immune response pathways.
eLife · Feb 18, 2025Peer-reviewedGenetics