Yun-Lin Wang

Multiplexed Assays of Human Disease-relevant Mutations Reveal UTR Dinucleotide Composition as a Major Determinant of RNA Stability

The paper identifies UA dinucleotides as a major determinant of RNA stability through UTR variants, linking them to disease and immune response pathways.

Massively Parallel Polyribosome Profiling Reveals Translation Defects of Human Disease-Relevant UTR Mutations

This study identifies UTR mutations that disrupt translation by altering polysome profiles and RNA structures, with a focus on uORF initiation sites and SRSF2 binding motifs.