Yen‐Tsung Huang

The paper develops population-specific polygenic risk scores for Han Chinese using genomic and electronic health record data, showing strong predictive performance for multiple diseases.

The Taiwan Precision Medicine Initiative (TPMI) recruits a large cohort for genetic and electronic medical record studies to advance precision medicine.

The paper evaluates the clinical impact of pharmacogenetic risk variants in a large Han Chinese cohort, finding that while most carry risk variants, the excess risk of adverse events is small and most patients do not experience adverse outcomes.

The paper identifies UA dinucleotides as a major determinant of RNA stability through UTR variants, linking them to disease and immune response pathways.

The paper analyzes 292 disease-relevant deleterious variants in 486,956 participants to assess their risk differences, finding most have minimal impact.

This study shows that autologous NK cell therapy activates dendritic and T cells in metastatic lungs and effectively treats low-burden metastases in a mouse model and a clinical trial.

This study identifies UTR mutations that disrupt translation by altering polysome profiles and RNA structures, with a focus on uORF initiation sites and SRSF2 binding motifs.