IDR-dependent MORC1 bodies limit chromatin accessibility to tune transposon repression
Yosuke Isota, Peilin Li, Kiichiro Sakata, Hiyu Chiwata, Hidetaka Kosako, Soichiro Yamanaka, Hiroya Yamazaki, Mikiko C. Siomi
The paper shows that MORC1 forms nuclear condensates to regulate transposon repression by limiting chromatin accessibility and focusing repression on specific targets.
bioRxiv · Dec 14, 2025 · PreprintMolecular Biology