Mikiko C. Siomi

Transient residence of the repulsive client Shutdown in Yb bodies plays a critical role in Piwi-piRISC biogenesis and maintaining fertility

The paper shows that Shutdown's transient presence in Yb bodies is crucial for Piwi-piRISC formation and fertility, mediated by its self-repulsion and interaction with Armitage.

IDR-dependent MORC1 bodies limit chromatin accessibility to tune transposon repression

The paper shows that MORC1 forms nuclear condensates to regulate transposon repression by limiting chromatin accessibility and focusing repression on specific targets.

Flamenco plasticity tunes somatic piRNAs, rewiring host isoforms and opening a route to heritable transposon spread

The paper shows how the transposon Springer rewires gene expression and how Flamenco piRNA clusters remodel to allow transposon spread to the germline.

Priming Epigenetic Landscape at Gene Promoters through Transcriptional Activation in Mammalian Germ Cells

The paper shows that in mouse male germ cells, promoter chromatin states are shaped by H3K4me3 density and H3K27me3 dynamics, influencing gene expression during development.

Diptera-specific Daedalus controls Zucchini endonucleolysis in piRNA biogenesis independent of exonucleases

The paper identifies Daedalus as a Diptera-specific protein that controls Zucchini endonucleolysis in piRNA biogenesis independently of exonucleases.

Role of ADMA-histones in dual-strand piRNA source locirecognition by Rhino

The paper investigates how ADMA-histones facilitate Rhino binding to dual-strand piRNA clusters in Drosophila, supporting piRNA production.

Morc1 re-establishes heterochromatin on activated transposons and shapes the host transcriptome in gonocytes

The paper shows Morc1 re-silences activated transposons in gonocytes by establishing heterochromatin, preventing their disruptive effects on the transcriptome.

An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori

This study identifies a novel interaction between BmGtsf1L and BmVreteno's eTudor domain that facilitates piRNA biogenesis in Bombyx mori by connecting piRNA-loaded BmAgo3 and Gtsf1L.

Hamster PIWI proteins bind to piRNAs with stage-specific size variations during oocyte maturation

This study investigates piRNA size variations and PIWI protein dynamics during hamster oocyte maturation, revealing stage-specific piRNA binding and transcriptional regulation in ovarian piRNA clusters.

Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing

The paper identifies Nxf2 as a key component in the Piwi-piRNA pathway, showing it forms complexes that stabilize Piwi and Panx and initiate co-transcriptional silencing of target transcripts.