Hidetaka Kosako

This study identifies AR-dependent Mybph repression as a mechanism contributing to skeletal muscle sexual dimorphism using ChIL-seq and an AirID-AR knock-in mouse.

This study identifies how NPM-ALK alters the TGM1 interactome to support oncogenic signaling and proliferation.

The paper identifies MIC11 as an essential gene for Toxoplasma gondii egress, showing it interacts with PLP1 to disrupt host cell membranes.

The paper shows that Shutdown's transient presence in Yb bodies is crucial for Piwi-piRISC formation and fertility, mediated by its self-repulsion and interaction with Armitage.

The paper identifies AIFM1 as an OMA1 substrate that, when cleaved under mitochondrial stress, reduces OXPHOS activity and suppresses cell growth.

The paper uses spatial proteomics to identify projection-specific molecular diversity in the prefrontal cortex and identifies BLTP2 as a key presynaptic protein involved in memory and behavior.

This study identifies LUBEL/RNF31 as a key regulator of T-tubule biogenesis through linear ubiquitination, showing its interaction with Amphiphysin and role in membrane tubulation.

The paper shows that MORC1 forms nuclear condensates to regulate transposon repression by limiting chromatin accessibility and focusing repression on specific targets.

This study identifies LRBA as a scaffold promoting MAPK activation, leading to drug-induced liver injury and MASLD by enhancing inflammatory signaling.

The paper identifies sex-biased transcriptome changes in Pax6 haploinsufficient mouse cortices and highlights Pbdc1 as a candidate regulator of sex-dependent corticogenesis.

The paper validates target proteins of heterobifunctional molecules using AirID, showing different interactome profiles based on E3 ligase binders.

This study identifies REFEE as a post-transcriptional regulator of repetitive RNAs that influences zygotic genome activation in mouse embryos.

This study identifies the BmMasc-BmPSI complex as essential for male-type Bmdsx splicing in silkworms by binding to female-specific introns and exons.

This study identifies the Rubicon-WIPI axis as a regulator of exosome biogenesis, showing its role in age-dependent exosome release and microRNA fate in mice.