Smith-Magenis syndrome protein RAI1 regulates body weight homeostasis through hypothalamic BDNF-producing neurons and neurotrophin downstream signalling
Sehrish Javed, Ya-Ting Chang, Yoobin Cho, Yu‐Ju Lee, Hao‐Cheng Chang, Minza Haque, Yu Cheng Lin, Wei‐Hsiang Huang
This study shows that RAI1 regulates body weight through hypothalamic BDNF neurons and neurotrophin signaling, and that targeting this pathway can delay obesity in SMS mice.
eLife · Aug 23, 2023Peer-reviewedNeuroscience