Yu‐Ju Lee

STARLING quantifies cell populations from spatial protein expression data while accounting for segmentation errors, identifying known cell types and quantifying heterogeneity in human tonsil tissue.

This paper introduces an IFFL-based CRISPR-Cas system to reduce gene expression variability, demonstrating improved dosage control for RAI1 in a mouse model.

This study shows that RAI1 regulates body weight through hypothalamic BDNF neurons and neurotrophin signaling, and that targeting this pathway can delay obesity in SMS mice.

The paper develops CNEP to predict constrained non-exonic bases using epigenomic and transcription factor data, and introduces CSS-CNEP to improve prediction for underperforming bases.