Molecular basis of BET family protein inhibition by four clinical-stage small-molecule inhibitor drugs
Sheng Lin, Yu You, Xi Chen, LU Guang-wen
This study investigates how four BET inhibitors bind to BRD2's bromodomain, revealing a shared mechanism of competitive inhibition and highlighting structural differences that may affect their pharmacological properties.
bioRxiv · Feb 6, 2026 · PreprintBiophysics