Xi Chen

Cryo-EM elucidation of stoichiometric plasticity, asymmetric ligand recognition and allosteric coupling in human P2X2/3 heterotrimeric channels

The paper reports cryo-EM structures of human P2X2/3 heterotrimers in different functional states, revealing asymmetric ligand recognition and allosteric coupling mechanisms.

Comparative study on the inhibition of copper oxide, nickel, and sodium tungstate on microbially induced concrete corrosion under sewer conditions

This study compares the inhibition effects of copper oxide, nickel, and sodium tungstate on microbially induced concrete corrosion under sewer conditions, finding that copper oxide and nickel show the most significant bacteriostatic effects.

Molecular basis of BET family protein inhibition by four clinical-stage small-molecule inhibitor drugs

This study investigates how four BET inhibitors bind to BRD2's bromodomain, revealing a shared mechanism of competitive inhibition and highlighting structural differences that may affect their pharmacological properties.

SPCoral: diagonal integration of spatial multi-omics across diverse modalities and technologies

SPCoral integrates spatial multi-omics data across different modalities and technologies, improving spatial domain identification and cross-modal analysis.