Author

LU Guang-wen

Sichuan UniversityORCID 0000-0001-7568-592XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

Sheng LiniD· 1 shared Xi CheniD· 1 shared Yu You· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBiophysics

Sheng LinORCID

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1 paper

Recent·Most cited

BiophysicsbioRxivPreprintFeb 6, 2026

Molecular basis of BET family protein inhibition by four clinical-stage small-molecule inhibitor drugs

Sheng Lin, Yu You, Xi Chen, LU Guang-wen

This study investigates how four BET inhibitors bind to BRD2's bromodomain, revealing a shared mechanism of competitive inhibition and highlighting structural differences that may affect their pharmacological properties.

DOI 10.64898/2026.02.05.704030

humanstructural biology

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